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Rue - Andrew / Rueben
If I had a Reuben, he would probably go by Rue. Drew is more common for Andrew, at least from what I've heard.
Ren - Laurence (I know this one was once used)
I really like Ren for a boy.
Roe - Rowan
This one would be okay.
Izzy - Isadore / Isaac
My nephew is named Isaac, but we call him IJ, because he's Isaac John. I think Izzy is fun to say, so I'd use this for an Isidore more likely.