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Lots of possibilities but most other than Chrys are slightly incredible, imo, including Santhe (unless she is said to have created it herself).
If it's her family using the nickname, you could go the route of older-sibling babytalk when they were too small to say the name. Samma or Sanna.

Sandy
Rys
San
Chryssy

not all nick names have to do with their names
but i will give my best try
Chrysanthe,Cyna, Cynthia, Syche. Psyche, Rane, Rants, Sanrye, Sana, Sate, Saedy, Satie, Sadie, Chryset, Chrase, Chrys, Cresta, Ran. Ray, Rae,Crest, Cress, Cressida, Cressita, Cyressa, Cryseta Chrisetta, Cresyna, Syna, Synte, Syndi, Cyndi, Candy, Nera, Nate, Natecha, Techa, Neta, Nachta, Tea, Thays, thais, Hecta, Hechra, Hesa, Hester
Heathar, Heather, Heatha, Heath,
Hera, Hattie, Hat, Hay, Hase, Hatch,
Cynthe, Taneya, Tanya, Trysta,
Tresa, Trena, Tryna, Santhe,Tansy,
Anrya, Crants, Crane, Crantsa,
Crea, Creta, Crey, Cray, Crae,
Chris, Christe, Christa, Chrysne
Shena, Stace, Tacey,
Trea, Tre, Treca, Tryxe, Rycha, Richea, Richa, Richy, Rica,
Sren, Sryn, Sera, Satyre, Tyra, Echa, Cane, Anta, therysa
, Cante, Caran, Cathe, Catha, Cathy, Cate, Racha, Ryanthe, Ryane,Ryanne, shante, Shane, Chase, Chante, Chaste, Chasa, Chesa, Chessie, Cheta, Rysa, Rysha, Rysh, Rasya, Chasy, shae, Shaye, Shay, Senca, Sancha, Sethe, Sethea, Thea, Taren, Taryn, Anthea, Annie, Ancrey, Ethany, Etha, Es, Essie, Tess,Tessa, Hana, Hannah, Haret,Harriet, Reta, Ryta, Rita, , Cyan, Syanne, Cheyanne,

Xanthe Anthee Chrissy Christy Christa

This message was edited 10/7/2022, 3:48 PM

Anthea
Christy
Xanthe

this is going to get confusing real quickly

I aways go for Chrysanne, like Chris-Anne

Maybe Rys prn. REES like Rhys or Reece?
Ann or Annie?
I also think of anthem but it's awful

Christie?
Kitty?

This message was edited 10/7/2022, 2:35 PM