Louise/Louisa nicknames:
LisaLiseIsa (ee-sa)
Loui (loo-ee)
They would definitely make good middle names. I don't love them enough to use them, but I sure would appreciate them on someone else's kiddo. Although in the middle name spot, I might also guess that they were honouring.
I like
Louisa better. I like the softer S sound than in
Louise.