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Well, Rune would be an out-of-place nickname for someone who is Christian-religious. Mostly because Rune (though applicable to all ancient faiths) are generally associated with Paganism in literature. Rue is also a sad meaning, which is not likely something Christian parents would use.

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But, either could technically work despite the unlikelihood, especially if the nickname was used to demonstrate a streak of rebellion in the character.

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I like the nickname - though it is a stretch from Veronica. If you could give it a decent back story (little brother caller her va-roon-ka, because he couldn't pronounce it and it evolved into simply roo or roon, Rue/Rune...) it could work for a written piece.

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Tony from Anthony doesn't change the base sound, which is why it works naturally. Especially since some accents pronounce Anthony as an-ton-ee.

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If it were me, and I didn't have a backstory to easily explain the nickname... I would pick something other than Veronica.

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"How wonderful it is that no one need wait a single moment before starting to improve upon the world." -Ann Frank
Mama to my "bright star" Clarisse Bituin and Wife to Julius. Mahal na mahal from our little family to yours!