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The last name Manzetti comes from the old personal name Manzetto, pet form of Manzo (see http://www.ancestry.com/facts/Manzo-family-history.ashx).
In Italy there's a certain number of last names coming from this old personal name, with variants in Manso and Mansueto (see http://www.ancestry.com/facts/Mansueto-family-history.ashx and http://www.ancestry.com/facts/Manso-family-history.ashx).
A famous example is the italian writer Alessandro Manzoni, one of the most popular writers in italian literature.