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These surnames are very difficult to explain.
At the moment in Italy they are extremely rare, except REGA that is more spread.

Pezzullo, derives probably, but I am not sure, from "pezzo", "pezzu"
in southern dialects of Italy. "-ullo" is a diminutive.
The meaning is "piece" or "bit".
It comes probably from a nickname. But what is the meaning?

Di Iorio means "son of George" since Iorio is a variant of Giorgio, Giorgio in Italian.

Moffa is probably a surname coming from a nickname. "moffa" and "muffa" could be in Italian "mould". Moffa is extremely rare.

Rega is the most common among these surnames.
The original meaning is not clear to me.
In Spain we can find Rego, a surname of locative origin.
Rega as surname existed or still exists in Britain, Belgium and some other country (see the Mormon site)
The italian variant could be at leasr partially of spanish origin? I don't know.
In Britain there are surname quite similar:
Regg
Reg...

I'm waiting for Sagani ...our Italian expert, but I'll venture a few guesses in the meantime ... and I am guessing!!

Pezzulo ... looks like it comes from a piece of cloth that has give rise to names of horses and rag dolls ...I think it ultimately means 'patch'...with the obvious diminutive -ullo ...son of, descendant of ...

Rega ...I'd guess has to do with "royalty" ...

DilOrio ...I'm going to really guess has something to do with "Orio" meaing maybe 'origin' or maybe 'gold' ...not sure ...I'd suspect tha the Dil- is basically like Del- meaning "of" ...

Best I can do ...help please Sangani!!!