As an English name it has been very popular since the Middle Ages. It was the top name for girls in England and Wales in the 1920s, 30s and 40s, but it declined in the latter half of the 20th century.
Other saints by this name include a queen of Scotland and a princess of Hungary. It was also borne by Queen Margaret I of Denmark, who united Denmark, Sweden, and Norway in the 14th century. Famous literary bearers include American writer Margaret Mitchell (1900-1949), the author of Gone with the Wind, and Canadian writer Margaret Atwood (1939-). Others include American anthropologist Margaret Mead (1901-1978) and British prime minister Margaret Thatcher (1925-2013).
This name was fairly popular at the end of the 19th century and beginning of the 20th. The American author F. Scott Fitzgerald used it for the character of Daisy Buchanan in The Great Gatsby (1925). The Walt Disney cartoon character Daisy Duck was created in 1940 as the girlfriend of Donald Duck. It was at a low in popularity in the United States in the 1970s when it got a small boost from a character on the television series The Dukes of Hazzard in 1979.