This name has never been common in the English-speaking world, though it has been well-used elsewhere in Europe. A famous bearer was the Italian Renaissance master Raffaello Sanzio (1483-1520), usually known simply as Raphael in English.
A city in Italy bears this name, though in this case it originates from Latin Mediolanum, perhaps ultimately of Celtic origin meaning "middle of the plain". In some cases the city name may be an influence on the use of the given name.
Although this name was borne by several early saints, including a pope, it was rare during the Middle Ages. It was revived in Italy and France during the Renaissance, and was subsequently imported to England.
Among Christians, this name was originally more common in Eastern Europe. It was borne in the 12th century by Saint Elizabeth of Hungary, a daughter of King Andrew II who used her wealth to help the poor. In medieval England it was occasionally used in honour of the saint, though the form Isabel (from Occitan and Spanish) was more common. It has been very popular in England since the reign of Queen Elizabeth I in the 16th century. In American name statistics (as recorded since 1880) it has never ranked lower than 30, making it the most consistently popular name for girls in the United States.
Besides Elizabeth I, this name has been borne (in various spellings) by many other European royals, including a ruling empress of Russia in the 18th century. Famous modern bearers include the British queen Elizabeth II (1926-2022) and actress Elizabeth Taylor (1932-2011).
In England, this Latin form has been used alongside the vernacular forms Ann and Anne since the late Middle Ages. Anna is currently the most common of these spellings in all English-speaking countries (since the 1970s), however the biblical form Hannah is presently more popular than all three.
The name was borne by several Russian royals, including an 18th-century empress of Russia. It is also the name of the main character in Leo Tolstoy's novel Anna Karenina (1877), about a married aristocrat who begins an ultimately tragic relationship with Count Vronsky.
As an English name it was highly popular from the Middle Ages until the 17th century. It was revived in the 19th century and was common into the 20th, but it fell into decline after the 1930s. It last appeared on the American top 1000 rankings in 1972.