It has occasionally been used as an English given name since the 16th century. It was moderately popular in the 1940s, but had a more notable upswing in the early 2000s. This may have been inspired by the Spanish actress Penélope Cruz (1974-), who gained prominence in English-language movies at that time. It was already rapidly rising when celebrities Kourtney Kardashian and Scott Disick gave it to their baby daughter in 2012.
A notable bearer of this name was Marie Antoinette, a queen of France who was executed by guillotine during the French Revolution. Another was Marie Curie (1867-1934), a physicist and chemist who studied radioactivity with her husband Pierre.
In France it is occasionally used as a masculine name in pairings such as Jean-Marie.