Due to the saint's popularity, the name came into general use in medieval Europe, especially in Spain and France. It was also borne by a 16th-century king of Portugal who died in a crusade against Morocco.
Very rare as an American given name before 1980, it increased in popularity in the 1980s and 90s. It got a boost in 2004 after the debut of the television series Lost, which featured a character by this name.
Other famous bearers of this name include Spanish painter Diego Velázquez (1599-1660), Mexican muralist Diego Rivera (1886-1957) and Argentine soccer player Diego Maradona (1960-2020).