In the English-speaking world this name is more commonly given to girls. This is due to the American actress Alexis Smith (1921-1993), who began appearing in movies in the early 1940s. It got a boost in popularity in the 1980s from a character on the soap opera Dynasty.
Before 1980, this was an uncommon masculine name in America. During the 1980s and 90s this name steadily increased in popularity for both boys and girls, and from 2003 onwards it has been more common for girls in the United States. Elsewhere in the English-speaking world, such as the United Kingdom and Australia, it has remained largely masculine.