In the English-speaking world this name is more commonly given to girls. This is due to the American actress Alexis Smith (1921-1993), who began appearing in movies in the early 1940s. It got a boost in popularity in the 1980s from a character on the soap opera Dynasty.
This name was popular throughout the English-speaking world in the early 20th century. It staged a comeback in the early 21st century, returning to the American top ten in 2017.
This name can also be given in reference to the city in Italy, as in the case of Florence Nightingale (1820-1910), who was born there to British parents. She was a nurse in military hospitals during the Crimean War and is usually considered the founder of modern nursing.
Due to the renown of the saint, this name became widespread in Western Europe during the Middle Ages. However, it was not regularly used in Britain until the 16th century. Famous bearers include Saint Francis Xavier (1506-1552), a missionary to East Asia, the philosopher and scientist Francis Bacon (1561-1626), the explorer and admiral Francis Drake (1540-1595), and Pope Francis (1936-).
In the English-speaking world this name is occasionally used for girls, as a variant of the homophone Frances.
This name is most of the time given for females, but rarely given to males, if given at all.
Other kanji combinations are possible.