I actually like
Xanthippe more than
Xanthe.
Xanthe is very cold and corporate-sounding, while
Xanthippe seems more "namey" and warm, as well as historical. I also love the playful and chirpy "ippe" ending. It has much more personality than
Xanthe does.
I think it's usable. It's certainly no weirder than
Xanthe, and has a historical background to boot.