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In the traditional rules of English spelling, a "c" followed by an "i" (or an e or y) is pronounced as "s". So many people will indeed look at Nici and pronounce it as Neesee or Nissy or Nicey. There also may be some people who will assume it's foreign and go for the "Neechee" pronunciation.

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In any event, Nici is not a good respelling for Nicki or Nikki.