I have an ancestor named
Sophronia! I think she was somewhere on my maternal grandmother's side. She apparently went by her middle name, which was something less remarkable (I want to say it was
Jane, although I could be mistaken). It's a bit much for a name, but hey, that's my favorite kind. It also makes me think of the word "symphony".
I honestly hadn't realized the possibility of
Sophie or
Sophia as nicknames until I read the other responses. That dampens my opinion of it a little, since I'm not fond of either.