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These surnames are very difficult to explain.
At the moment in Italy they are extremely rare, except REGA that is more spread.

Pezzullo, derives probably, but I am not sure, from "pezzo", "pezzu"
in southern dialects of Italy. "-ullo" is a diminutive.
The meaning is "piece" or "bit".
It comes probably from a nickname. But what is the meaning?

Di Iorio means "son of George" since Iorio is a variant of Giorgio, Giorgio in Italian.

Moffa is probably a surname coming from a nickname. "moffa" and "muffa" could be in Italian "mould". Moffa is extremely rare.

Rega is the most common among these surnames.
The original meaning is not clear to me.
In Spain we can find Rego, a surname of locative origin.
Rega as surname existed or still exists in Britain, Belgium and some other country (see the Mormon site)
The italian variant could be at leasr partially of spanish origin? I don't know.
In Britain there are surname quite similar:
Regg
Reg...