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Scottish originally, "son of Bryce", which was the name of a fifth century saint, Bishop of Tours. The Scots took a liking to the name for some reason.
There are also Irish Brysons, who started out with another name, O Muirghesain. The name was pronounced O'Mrisawn, then O'Brisawn, so Bryson seemed a suitable English version. Some who settled in the Hebrides became Morrisons, while others,who moved from their Donegal homeland to the County Mayo, ended up with the surname Price. Lost their language, lost their name.