Means "Son of Samp".
The Domesday Book has an entry for "Sampson's Farm," in Essex, England, in 1086. History says that the surname was brought to Britain by the Normans, in 1066, where the letter p was added. The surname made its way to America in the 17th century. Over the centuries, it independently popped up in other locations as well, with different spellings, owing to its biblical origin. It's often confused with the name Simpson. Since Simpsons tend to favor business, while Sampsons tend to favor academia, I'll sometimes joke that Simpsons tend to have more money than Sampsons, but Sampsons tend to be smarter than Simpsons.

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