Surname in brackets:
Jensen
Ross (Ackles) has an older brother
Joshua and younger sister
Mackenzie.
Thomas John Patrick (Welling) has 2 older sisters
Rebecca and
Jamie and a younger brother
Mark.
Thomas Cruise IV (Mapother) has 3 sisters,
Lee Anne,
Marian and
CassChanning Bryan Isaac Tatum (
Anderson).
Jared Tristan (Padalecki) has an older brother
Jeff and younger sister
Megan.
John Christopher (Depp) has a brother
Daniel P and sisters
Christie and
Debbie.
Matthew Paige (
Damon) has a brother
Kyle.
Benjamin Geza (Affleck) has brother
Caleb Casey.
Jennifer Lynn (Lopez) has sisters
Leslie and
Lynda.
Jennifer Anne (Garner) has sisters
Melissa and
Susannah.
Kimberley Alexis (Bledel) has a brother
Eric David.
Julia Fiona (
Roberts) has a brother
Eric and sisters
Lisa and
Nancy.
Matthew Ryan (Phillippe) has sisters
Kirsten,
Lindsay and
Katelyn.
Laura Jeanne Reese (Witherspoon) has a brother
John Draper.
Alicia Christian ('
Jodie'
Foster) has sisters
Lucinda and
Constance and a brother
Lucius.
John Joseph (Travolta) has brothers
Joey and
Sam and sisters
Ellen,
Ann and
Margaret.
And the most interesting set:
Uma Karuna (Thurman) has a sister Taya and brothers Ganden, Dechen and Mipam.