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Hmm, I'm not sure it would work to be honest. I think the reason for choosing a nickname is that the given name is too long or too formal sounding for everyday use. However Alexandra is still a long name in itself. Also it's so similar to Alexandria that I think it would create confusion for other people about which was the "correct" name.

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I personally think if you love the name Alexandria (and have done for a long time) then use that but go for something more obviously nicknamey and less formal as a nickname (if you need to) e.g. Lex, Lexie, Alex, Alexa (I like this as a full name but it can work as a nickname), Ria, Sandie etc.