Namesakes
Brazilian Presidents:
1 president
Washington Luís (a.k.a. de Sousa) 1926-1930 
Olympic Medalists:
1 silver/gold
(silver/gold) Carlos Lopes (a.k.a. de Sousa) 1976; 1984 10000 m; marathon
Portuguese Presidents and Prime Ministers:
5 prime ministers, 1 president
(prime minister) Vitório Maria de Sousa Coutinho 1835
(prime minister) Pedro de Sousa Holstein 1834-1835; 1842; 1846
(prime minister) Sebastião Custódio de Sousa Teles 1909
(prime minister) António Teixeira de Sousa 1910
(prime minister) José Sócrates (a.k.a. de Sousa) 2005-2011
(president) Marcelo Rebelo de Sousa 2016-
Saints:
1 saint
Saint Dulce of the Poor (a.k.a. de Sousa) 1914-1992