Namesakes
Notable Actors and Entertainers:
3 actors
Yvonne De Carlo (a.k.a. Middleton) 1922-2007 
Ben Vereen (a.k.a. Middleton) 1946-
Tuppence Middleton 1987-
Notable Musicians:
1 singer
Yvonne De Carlo (a.k.a. Middleton) 1922-2007
Notable Writers:
1 author
Stanley Middleton 1919-2009
Olympic Medalists:
1 gold
(gold) Khris Middleton 2020 basketball
Other Royalty:
1 princess
Catherine, Princess of Wales (a.k.a. Middleton) 2011- United Kingdom
Saints:
2 blessed
Blessed Robert Middleton 1571-1601
Blessed Anthony Middleton ?-1590