Namesakes
American First Ladies:
1 first lady
Frances Cleveland (a.k.a. Preston) 1886-1889; 1893-1897 
Fictional Characters from Television:
1 character
John James "Mr. Big" Preston 1998; 2021 Sex and the City; And Just Like That...
Notable Actors and Entertainers:
4 actors
Robert Preston 1918-1987
Kelly Preston 1962-2020
Carrie Preston 1967-
Reagan Gomez-Preston 1980-
Notable Filmmakers:
1 director
Carrie Preston 1967-
Notable Musicians:
1 musician
Billy Preston 1946-2006