Namesakes
Fictional Characters from Television:
1 character
Grace Santiago 2003 Nip/Tuck 
Notable Actors and Entertainers:
1 actor
Saundra Santiago 1957-
Notable Musicians:
1 singer
Anuel AA (a.k.a. Santiago) 1992-
Rock and Roll Hall-of-Famers:
1 musician
Herman Santiago 1993 The Teenagers
Saints:
1 blessed
Blessed Carlos Manuel Rodríguez Santiago 1918-1963