Save Type Surname (from location) Usage Spanish, Basque Meaning & History From the name of a place name near the town of Azpeitia in the Basque Country of Spain, derived from Basque loi meaning "mud". This was the birthplace of Saint Ignatius of Loyola (1491-1556), the founder of Jesuits. Related Names RootLoyola/Loiola (place name) Categories earth