Save Type Surname (from nickname) Usage Portuguese, Spanish Pronounced Pron. SAN-tos(Spanish) [key·IPA] Meaning & History Means "saint" in Portuguese and Spanish, ultimately from Latin sanctus. This was a nickname for a pious person. Related NamesDetails Other Languages & CulturesDe Santis, Santo, Santoro, Santini(Italian) Entry updated November 16, 2019
